Revolutionizing Animal Health: The Role of Nanoparticles in Veterinary Medicine

Muhammad Umar Sharif *

Department of Anatomy, Faculty of Veterinary Science, University of Agriculture, Faisalabad-38000, Pakistan.

Muhammad Usman

Faculty of Veterinary Science, University of Agriculture, Faisalabad-38000, Pakistan.

Hafiz Muhammad Aslam

Department of Biochemistry, University of Agriculture, Faisalabad-38000, Pakistan.

Muhammad Abdullah

Department of Anatomy, Faculty of Veterinary Science, University of Agriculture, Faisalabad-38000, Pakistan.

Muhammad Usman

Department of Biosciences, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan- 60800, Pakistan.

*Author to whom correspondence should be addressed.


Abstract

Nanoparticles (NPs) have opened new doors in veterinary disease detection, therapy, and prevention. These particles have many functions due to their designed, inadvertent, and natural origins. NPs including quantum dots, iron oxide, gold, silver, dendrimers, liposomes, carbon-based, and polymeric NPs have unique functions and are better for biomedical applications. Characterization procedures include SEM, TEM, AFM, and Zeta Potential studies help understands NP characteristics. Veterinary medicine uses NPs in several ways. They aid disease diagnosis, including neurological disorders and mastitis prevention. Silver and copper NPs are effective against Staphylococcus aureus and E. coli. Nanoparticles also boost immune responses and target infections, including zoonotic diseases, improving vaccine development. Neospora caninum uses neo glycolipid-coated liposomes to induce neosporosis and high cellular and humoral immunity. Besides treatments, NPs improve the health status of animals by increasing reproductive, immunity, and growth performance.  Pet care products and breeding methods use them for long-term gamete preservation, fertility control, and reproductive health assessment. Exploring transdisciplinary uses, standardizing characterization, and lowering toxicity are the future of veterinary nanomedicine. To employ NPs in veterinary medicine, standard methods and complete preclinical evaluations are needed.

Keywords: Nanoparticles, nanotechnology, antimicrobial, vaccine development, reproductive health, nanomedicine


How to Cite

Sharif , Muhammad Umar, Muhammad Usman, Hafiz Muhammad Aslam, Muhammad Abdullah, and Muhammad Usman. 2024. “Revolutionizing Animal Health: The Role of Nanoparticles in Veterinary Medicine”. Asian Journal of Research in Animal and Veterinary Sciences 7 (3):196-207. https://journalajravs.com/index.php/AJRAVS/article/view/304.

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References

Sajid M, Płotka-Wasylka J, Nanoparticles: Synthesis, characteristics, and applications in analytical and other sciences. Microchemical Journal. 2020;154:104623.

Prasad RD, et al. A review on concept of nanotechnology in veterinary medicine. ES Food & Agroforestry. 2021;4:28-60.

Xie J, et al. Arsenic and selenium distribution and speciation in coal and coal combustion by-products from coal-fired power plants. Fuel. 2021;292: 120228.

Bakkar A, et al. Recovery of vanadium and nickel from heavy oil fly ash (HOFA): A critical review. RSC advances. 2023;13(10):6327-6345.

Barhoum A, et al. Review on natural, incidental, bioinspired, and engineered nanomaterials: History, definitions, classifications, synthesis, properties, market, toxicities, risks, and regulations. Nanomaterials. 2022;12(2):177.

Calderón-Garcidueñas L, Ayala A, Air Pollution, ultrafine particles, and your brain: Are combustion nanoparticle emissions and engineered nanoparticles causing preventable fatal neurodegenerative diseases and common neuropsychiatric outcomes? Environmental Science & Technology. 2022;56(11):6847-6856.

Maroufpour N, et al. Biogenic nanoparticles in the insect world: Challenges and constraints. Biogenic Nano-Particles their Use in Agro-ecosystems. 2020;173-185.

Jeevanandam J, et al. Review on nanoparticles and nanostructured materials: History, sources, toxicity and regulations. Beilstein Journal of Nanotechnology. 2018;9(1):1050-1074.

Shalan AI, et al. Nanofibers as promising materials for new generations of solar cells, in Handbook of Nanofibers. Springer Nature Switzerland AG. 2018;1-33.

Huang H, et al. Inorganic nanoparticles in clinical trials and translations. Nano Today. 2020;35:100972.

Montiel Schneider MG, et al. Biomedical applications of iron oxide nanoparticles: Current insights progress and perspectives. Pharmaceutics. 2022;14(1):204.

Huang Y, et al. Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle. Theranostics. 2022;12(2):796-816.

Sani A, Cao C, Cui D, Toxicity of gold nanoparticles (AuNPs): A review. Biochemistry and Biophysics Reports. 2021;26:100991.

Barrett JP, et al. An In vitro study into the antimicrobial and cytotoxic effect of Acticoat™ dressings supplemented with chlorhexidine. Burns. 2022;48(4):941-951.

Yin IX, et al. The antibacterial mechanism of silver nanoparticles and its application in dentistry. International Journal of Nanomedicine. 2020;2555-2562.

Singh V, Sahebkar A, Kesharwani P, Poly (propylene imine) dendrimer as an emerging polymeric nanocarrier for anticancer drug and gene delivery. European Polymer Journal. 2021; 158:110683.

Sztandera K, Rodríguez-García JL, Ceña V, In vivo applications of dendrimers: A step toward the future of nanoparticle-mediated therapeutics. 2024;16(4):439.

De Leo V, et al. Liposomes containing nanoparticles: Preparation and applications. Colloids and Surfaces B: Biointerfaces. 2022;218:112737.

Vyas M, et al. Drug delivery approaches for doxorubicin in the management of cancers. Current Cancer Therapy Reviews. 2020;16(4):320-331.

Debnath SK, Srivastava R, Drug delivery with carbon-based nanomaterials as versatile nanocarriers: Progress and prospects. Frontiers in Nanotechnology. 2021;3:644564.

Martínez-López AL, et al. Protein-based nanoparticles for drug delivery purposes. International Journal of Pharmaceutics. 2020;581:119289.

Khalilov R, A comprehensive review of advanced nano-biomaterials in regenerative medicine and drug delivery. Advances in Biology & Earth Sciences. 2023;8(1).

Castro KCD, Costa JM, Campos MGN, Drug-loaded polymeric nanoparticles: A review. International Journal of Polymeric Materials & Polymeric Biomaterials. 2022;71(1):1-13.

Sakhi M, et al. Design and characterization of paclitaxel-loaded polymeric nanoparticles decorated with trastuzumab for the effective treatment of breast cancer. Frontiers in Pharmacology. 2022;13:855294.

Kianfar E, Protein nanoparticles in drug delivery: Animal protein, plant proteins and protein cages, albumin nanoparticles. Journal of Nanobiotechnology. 2021;19(1):159.

Qian C, et al. Recent progress on the versatility of virus-like particles. Vaccines. 2020;8(1):139.

Li M, et al. Virus-like particle-templated silica-adjuvanted nanovaccines with enhanced humoral and cellular immunity. ACS nano. 2022;16(7):10482-10495.

Manzano M, Vallet‐Regí M, Mesoporous silica nanoparticles for drug delivery. Advanced Functional Materials. 2020;30(2):1902634.

Ahmadi F, et al. A review on the latest developments of mesoporous silica nanoparticles as a promising platform for diagnosis and treatment of cancer. International Journal of Pharmaceutics. 2022;625:122099.

Zhou Z, Vázquez-González M, Willner IJCSR, Stimuli-responsive metal–organic framework nanoparticles for controlled drug delivery and medical applications. 2021;50(7):4541-4563.

Cai M, et al. Metal organic frameworks as drug targeting delivery vehicles in the treatment of cancer. Pharmaceutics. 2020;12(3):232.

Thakur A, et al. Recent advancements in surface modification, characterization and functionalization for enhancing the biocompatibility and corrosion resistance of biomedical implants. Coatings. 2022;12(10):1459.

Ilett M, et al. Analysis of complex, beam-sensitive materials by transmission electron microscopy and associated techniques. Philosophical Transactions of the Royal Society A. 2020;378(2186):20190601.

Ii S, Quantitative characterization by transmission electron microscopy and Its application to interfacial phenomena in crystalline materials. Materials. 2024;17(3):578.

Sarkar A, Biosensing, characterization of biosensors, and improved drug delivery approaches using atomic force microscopy: A review. Frontiers in Nanotechnology. 2022;3.

Joudeh N, Linke DJJoN, Nanoparticle classification, physicochemical properties, characterization, and applications: A comprehensive review for biologists. 2022;20(1):262.

Perciani CT, et al. Enhancing immunity with nanomedicine: Employing nanoparticles to harness the immune system. ACS nano. 2020;15(1):7-20.

Yao Y, et al. Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance. Frontiers in Molecular Biosciences. 2020;7:193.

Luo S, et al. Application of iron oxide nanoparticles in the diagnosis and treatment of neurodegenerative diseases with emphasis on Alzheimer’s disease. Frontiers in Cellular Neuroscience. 2020; 14:21.

Nguyen TT, et al. Recent advancements in nanomaterials: A promising way to manage neurodegenerative disorders. Molecular Diagnosis. 2023;27(4): 457-473.

Jagaran K, Singh M, Nanomedicine for neurodegenerative disorders: Focus on Alzheimer’s and Parkinson’s diseases. International Journal of Molecular Sciences. 2021;22(16):9082.

Woldeamanuel KM, Kurra FA, Roba YT, A review on nanotechnology and its application in modern veterinary science. International Journal of Nanomaterials, Nanotechnology and Nanomedicine. 2021;7(1):026-031.

da Silva Junior RC. et al. Development and applications of safranine-loaded Pluronic® F127 and P123 photoactive nanocarriers for prevention of bovine mastitis: In vitro and In vivo studies. Dyes and Pigments. 2019;167:204-215.

Zhang M, et al. High stability au nps: From design to application in nanomedicine. International Journal of Nanomedicine. 2021;6067-6094.

El-Sayed A, Kamel M, Advanced applications of nanotechnology in veterinary medicine. Environmental Science and Pollution Research. 2020;27:19073-19086.

Bārzdiņa A, et al. From polymeric nanoformulations to polyphenols—strategies for enhancing the efficacy and drug delivery of gentamicin. Antibiotics. 2024;13(4):305.

Seong M, Lee DG, Silver nanoparticles against Salmonella enterica serotype typhimurium: Role of inner membrane dysfunction. Current Microbiology. 2017;74:661-670.

Bruna T, et al. Silver nanoparticles and their antibacterial applications. International Journal of Molecular Sciences. 2021;22(13):7202.

Gomaa EZ, Silver nanoparticles as an antimicrobial agent: A case study on staphylococcus aureus and Escherichia coli as models for gram-positive and gram-negative bacteria. The Journal of General and Applied Microbiology. 2017;63(1):36-43.

Salleh A, et al. The potential of silver nanoparticles for antiviral and antibacterial applications: A mechanism of action. Nanomaterials. 2020;10(8):1566.

Kowalska-Krochmal B, Dudek-Wicher R, The minimum inhibitory concentration of antibiotics: Methods, Interpretation, Clinical Relevance. Pathogens. 2021;10(2):165.

Gheibi Hayat SM, Darroudi M, Nanovaccine: A novel approach in immunization. Journal of Cellular Physiology. 2019;234(8):12530-12536.

Vuppu S, et al. Nanovaccines for veterinary applications. Nanocarrier vaccines: Biopharmaceutics‐Based Fast Track Development. 2024;423-464.

Fereig RM, et al. Neospora GRA6 possesses immune-stimulating activity and confers efficient protection against Neospora caninum infection in mice. Veterinary Parasitology. 2019;267:61-68.

Nishikawa Y, Towards a preventive strategy for neosporosis: Challenges and future perspectives for vaccine development against infection with Neospora caninum. Journal of Veterinary Medical Science. 2017;79(8):1374-1380.

Abdelnour SA, et al. Nanominerals: Fabrication methods, benefits and hazards, and their applications in ruminants with special reference to selenium and zinc nanoparticles. Animals. 2021;11(7):1916.

Rahman HS, et al. Beneficial and toxicological aspects of zinc oxide nanoparticles in animals. Veterinary Medicine & Science. 2022;8(4): 1769-1779.

El-Maddawy ZK, et al. Use of zinc oxide nanoparticles as anticoccidial agents in broiler chickens along with Its impact on growth performance, antioxidant status and hematobiochemical profile. Life. 2022;12(1):74.

Omerović N, et al. Antimicrobial nanoparticles and biodegradable polymer composites for active food packaging applications. Comprehensive Reviews in Food Science Food Safety. 2021;20(3):2428-2454.

Thirugnanasambandan T, Gopinath SC. Nanomaterials in food industry for the protection from mycotoxins: An update. Biotech. 2023;13(2):64.

Malyugina S, et al. Biogenic selenium nanoparticles in animal nutrition: A review. Agriculture. 2021;11(12):1244.

Mekonnen G, Review on application of nanotechnology in animal health and production. J. Nanomed. Nanotechnol. 2021;12:559.

Abdelsalam M, et al. Effect of silver nanoparticle administration on productive performance, blood parameters, antioxidative status, and silver residues in growing rabbits under hot climate. Animals. 2019;9(10):845.

Bhat IA, Nanotechnology in reproduction, breeding and conservation of fish biodiversity: Current status and future potential. Reviews in Aquaculture. 2023;15(2):557-567.

Bisla A, Honparkhe M, Srivastava N, A review on applications and toxicities of metallic nanoparticles in mammalian semen biology. Andrologia. 2022;54(11): e14589.

Shandilya R, et al. Nanotechnology in reproductive medicine: Opportunities for clinical translation. Clinical Experimental Reproductive Medicine. 2020;47(4):245.

Abbas G, et al. Current prospects of nanotechnology uses in animal production and its future scenario. Pakistan Journal of Science. 2022;74(3):203-222.

Najafi A, et al. Effect of resveratrol-loaded nanostructured lipid carriers supplementation in cryopreservation medium on post-thawed sperm quality and fertility of roosters. Animal Reproduction Science. 2019;201:32-40.

Kansotia K, et al. Nanotechnology-driven Solutions: Transforming agriculture for a sustainable and productive future. Journal of Scientific Research and Reports. 2024;30(3):32-51.

Meng YQ, et al. Recent trends in preparation and biomedical applications of iron oxide nanoparticles. Journal of Nanobiotechnology. 2024;22(1):24.

Nanda SS, Yi DK, Recent advances in synergistic effect of nanoparticles and Its biomedical application. 2024;25(6):3266.

Khursheed R, et al. Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives. Biomedicine & Pharmacotherapy. 2022;150:112951.