Role of Selenium in Ruminants Health and Reproduction

Shalini Vaswani *

Department of Animal Nutrition, C. V. Sc and A. H. DUVASU, Mathura, India.

Sunil Kumar

Department of Animal Nutrition, C. V. Sc and A. H. DUVASU, Mathura, India.

*Author to whom correspondence should be addressed.


Selenium (Se), a micro element was well known for its toxicity at  earlier times. But, presently it is listed to be an essential mineral which is required for sound health, better immunity, and efficient reproductive functions of livestock. There is variation in the status of Se in animals and plants across the world based on different geological conditions.  Se concentrations of plants are closely related with those of its soil concentration. The deficiency of Se is associated  with many health problems viz  increased neonatal mortality, lowered immunity poor suckling reflex and white muscle disease in animals. There is significant role of Se in the reproduction of animals. The selenoproteins such as, Glutathione peroxidase 4 (GSH-Px4) and SELENOP have a regulatory role in male reproduction. GSH-Px4 has distinct antioxidant and structural properties and is expressed in testes. The peroxidation of Leydig cells is protected by SELENOP. The specific role of Se involves development of seminiferous tubules, growth of testicular tissues, in process of spermatogenesis, steroidogenesis and in synthesis and secretion of reproductive hormones like follicular stimulating hormone (FSH) and luteinizing hormone (LH). In female reproduction, the supplementation of Se may reduce the incidence of metritis and ovarian cysts and decreases the embryonic mortality. Currently, due attention is given on dietary Se supplementation through different (inorganic, organic and nano) forms of Se.

Keywords: Selenium, neonatal mortality, energy metabolism, animal health

How to Cite

Vaswani, Shalini, and Sunil Kumar. 2023. “Role of Selenium in Ruminants Health and Reproduction”. Asian Journal of Research in Animal and Veterinary Sciences 6 (2):167-73.


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Eruvbetine D. Canine Nutrition and Health. A paper presented at the seminar organized by Kensington Pharmaceuticals Nig. Ltd, Lagos; 2003.

Underwood EJ, Suttle NF. The mineral nutrition of livestock. CABI Publication, New York, USA; 1999.

Bhalakiya N, Haque N, Patel P, Joshi P. Role of Trace Minerals in Animal Production and Reproduction. International Journal of Livestock Research. 2019; 9(9):1-12.

Soetan KO, Olaiya CO, Oyewole OE. The importance of mineral elements for humans, domestic animals and plants-A review. African Journal of Food Science. 2010;4(5):200-222.

Pilarczyk B, Tomza-Marciniak A, Dobrzański Z, Szewczuk M, Stankiewicz T, Gaczarzewicz D, Lachowski W. The effect of selenized yeast supplementation on some performance parameters in sheep. Turkish Journal of Veterinary and Animal Sciences. 2013;37(1):61-67.

Keshri A, Roy D, Kumar V, Kumar M, Kushwaha R, Vaswani S. Impact of different source chromium sources on physiological response, blood biochemicals and endocrine status of heat stress in dairy calves. Biological Rhythm Research. 2022;53(1):58-69.

Singh A, Kumar M, Kumar V, Roy D, Kushwaha R, Vaswani S. Effect of Nickle supplementation on antioxidant status, immune characteristics and energy and lipid metabolism in growing cattle. Biological Trace Element Research. 2019;190(1):65-75.

Vaswani S, Mani V, Kewalramani N, Kaur H.. Mitigation of adverse effects of arsenic by supplementing vitamin E in crossbred kids maintained at low protein diet. Indian journal of Animal Nutrition. 2010;27(4): 346-352.

Praveen Kumar Gupta, Shalini Vaswani, Vinod Kumar, Debashis Roy, Muneendra Kumar, Raju Kushwaha, Avinash Kumar, Amit Shukla. Investigations on Modulating Effect of Vanadium Supplementation on Growth and Metabolism Through Improved Immune Response, Antioxidative Profile and Endocrine Variables in Hariana heifers. Biological trace element research. 194:379-389.

Gupta PK, Vaswani S. Basic information about vanadium 'ultra-trace element or occasionally beneficial element'and its various functions in animals: A review article.J. Entomol. Zool. Stud. 2020;8: 645-53

Rashid A, Ryan J. Micronutrient constraint to crop production in the near east potential significance and management strategies. Micronutrient Deficiencies in Global Crop Production; 2008,


National Research Council. Nutrient requirements of dairy cattle. National Academies Press. Washington, DC, USA; 2001.

Khanal DR, Knight AP. Selenium: Its Role in Livestock Health and Productivity. Journal of Agriculture and Environment. 2010;11:101-106.

Fordyce F. Selenium deficiency and toxicity in the environment. In ‘Essentials of medical geology–Impacts of the natural environment on public health’ (Eds O Selinus B Alloway JA Centeno RB Finkelman R Fuge U Lindh P Smedley). 2005;373-415.

Verma AK, Kumar A, Rahal A, Kumar V, Roy D. Inorganic versus organic selenium supplementation: a review. Pakistan Journal of Biological Sciences. 2012; 15(9):418-425.

Netto AS, Zanetti MA, Correa LB, Del Claro GR, Salles MSV, Vilela FG.. Effects of dietary selenium sulphur and copper levels on selenium concentration in the serum and liver of lamb. Asian-Australasian Journal of Animal Sciences. 2014;27(8):1082

Patterson EL, Milstrey R, Stokstad ELR. Effect of selenium in preventing exudative diathesis in chicks. Proceedings of the society for experimental Biology and Medicine. 1957; 95(4):617-620.

Sordillo LM. Selenium-dependent regulation of oxidative stress and immunity in periparturient dairy cattle. Hindawi Publishing Corporation. Veterinary Medicine International; 2013.

Pappas AC, Zoidis E, Surai PF, Zervas G. Selenoproteins and maternal nutrition. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2008;151(4):361-372.

Navarro-Alarcon M, Cabrera-Vique C. Selenium in food and the human body: a review. Science of the Total Environment. 2008;400(1-3):115-141.

Chauhan SS, Celi P, Ponnampalam EN, Leury BJ, Liu F, Dunshea FR. Antioxidant dynamics in the live animal and implications for ruminant health and product (meat/milk) quality:role of vitamin E and selenium. Animal Production Science. 2014;54(10):1525-1536.

Hogan JS, Smith KL, Weiss WP, Todhunter DA, Schockey WL. Relationships among vitamin E, selenium, and bovine blood neutrophils. Journal of Dairy Science. 1990;73(9):2372–2378

Hall JA, Bobe G, Vorachek WR, Gorman ME, Mosher WD, Pirelli GJ. Effects of feeding selenium-enriched alfalfa hay on immunity and health of weaned beef calves. Biological Trace Element Research. 2013;156(1-3):96-110.

Rock MJ, Kincaid RL, Carstens GE.. Effects of prenatal source and level of dietary selenium on passive immunity and thermo metabolism of newborn lambs. Small Ruminant Research. 2001;40(2): 129-138.

Rossi CS, Compiani R, Baldi G, Muraro M, Marden JP, Rossi R, Pastorelli G, Corino C, Dell'Orto V. Organic selenium supplementation improves growth parameters, immune and antioxidant status of newly received beef cattle. Journal of Animal and Feed Sciences. 2017;26(2):100-108.

Foresta C, Flohe L, Garolla A, Roveri A, Ursini F, Maiorino M. Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase. Biology of Reproduction. 2002;67(3): 967-971.

Olson GE, Winfrey VP, Nagdas SK, Hill KE, Burk RF. Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis. Journal of Biological Chemistry. 2007;282(16):12290–12297.

Fujii J, Iuchi Y, Matsuki S, Ishii T. Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues. Asian Journal of Andrology. 2003;5(3):231-242.

Aitken RJ, Buckingham D, Harkiss D. Use of a xanthine oxidase free radical generating system to investigate the cytotoxic effects of reactive oxygen species on human spermatozoa. Reproduction. 1993;97(2):441-450.

Makker K, Agarwal A, Sharma R. Oxidative stress and male infertility. Indian Journal of Medicine Research. 2009;129(4):357– 67.

Aitken RJ, Baker MA. Oxidative stress and male reproductive biology. Reproduction, Fertility and Development. 2004;16(5): 581-588.

Bilodeau JF, Chatterjee S, Sirard MA, Gagnon C. Levels of antioxidant defenses are decreased in bovine spermatozoa after a cycle of freezing and thawing. Molecular Reproduction and Development: Incorporating Gamete Research. 2000; 55(3):282-288.

Raijmakers MT, Roelofs HM, Steegers EA, Mulder TP, Knapen MF, Wong WY, Peters WH. Glutathione and glutathione S-transferases A1-1 and P1-1 in seminal plasma may play a role in protecting against oxidative damage to spermatozoa. Fertility and Sterility. 2003; 79(1):169-172.

Flohe L.. Selenium in mammalian spermiogenesis. Biological Chemistry. 2007;388(10):987-995.

Bedwal RS, Bahuguna A. Zinc copper and selenium in reproduction. Experientia. 1994;50(7):626-640.

Shi L, Zhang C, Yue W, Shi L, Zhu X, Lei F. Short-term effect of dietary selenium-enriched yeast on semen parameters, antioxidant status and Se concentration in goat seminal plasma. Animal Feed Science and Technology. 2010;157(1-2): 104-108.

Marin-Guzman J, Mahan DC, Pate JL. Effect of dietary selenium and vitamin E on spermatogenic development in boar. Journal of Animal Science. 2000;78(6): 1537-1543.

Li-Guang S, Ru-Jiea Y, Wen-Bina Y, Wen-Juana X, Chun-Xianga Z, You-Shea R, Lei AS, Fu-Linb L. Effect of elemental nano-selenium on semen quality, glutathione peroxidase activity, and testis ultrastructure in male Boer ram. Animal Reproduction Science. 2010;118:248–254.

Kendall N, McMullen S, Green A, Rodway R. The effect of a zinc cobalt and selenium soluble glass bolus on trace element status and semen quality of ram lambs. Animal Reproduction Science. 2000;62(4): 277–283.

Ebeid TA. Vitamin E and organic selenium enhances the antioxidative status and quality of chicken cockerel semen under high ambient temperature. British Poultry Science. 2012;53(5):708-714.

Enjalbert F, Lebreton P, Salat O. Effects of copper, zinc and selenium status on performance and health in commercial dairy and beef herds:retrospective study. Journal of Animal Physiology and Animal Nutrition. 2006;90(11-12):459- 466.

Kohrle J, Jakob F, Contempre B, Dumont JE. Selenium, the thyroid, and the endocrine system. Endocrine Reviews. 2005;26(7):944-984.

Pappas AC, Zoidis E, Surai PF, Zervas G.. Selenoproteins and maternal nutrition. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2008;151(4):361-372.

Burk RF, Hill KE. Regulation of selenium metabolism and transport. Annual Review of Nutrition. 2015;35:109-134.

Kachuee R, Moeini MM, Souri M. The effect of dietary organic and inorganic selenium supplementation on serum Se Cu Fe and Zn status during the late pregnancy in Merghoz goats and their kids. Small Ruminant Research. 2013;110(1):20-2

Xu DX, Shen HM, Zhu QX, Chua L, Wang QN, Chia SE, Ong CN. The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2003;534(1-2):155-163.

Zhang J, Wang X, Xu T. Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methyl selenocysteine in mice. Toxicological Sciences. 2008;101(1):22-31.

Wang Y, Yan X, Fu L. Effect of selenium nanoparticles with different sizes in primary cultured intestinal epithelial cells of crucian carp, Carassius auratus gibelio. International Journal of Nanomedicine. 2013;8:4007.

Shi L, Xun W, Yue W, Zhang C, Ren Y, Liu Q, Wang Q, Shi L. Effect of elemental nano-selenium on feed digestibility, rumen fermentation, and purine derivatives in sheep. Animal Feed Science and Technology. 2011;163(2-4):136-142.

Zhang JS, Gao XY, Zhang LD, Bao YP. Biological effects of a nano red elemental selenium. Biofactors. 2001;15(1):27-38.

Yaghmaie PA, Ramin S, Asri-Rezaei A, Zamani. Evaluation of glutathione peroxidase activity trace minerals and weight gain following administration of selenium compounds in lambs. Veterinary Research Forum. 2017; 8(2):133–137.