Effect of Turmeric (Curcuma longa) Extract with Zinc Oxide Nanoparticles Application on Burn Wound

Reduanul Hoque *

Department of Physiology and Pharmacology, Faculty of Veterinary and Animal Science, Hajee Mohammad Danesh Science and Technology University (HSTU), Bangladesh.

Rakibul Islam

Department of Physiology and Pharmacology, Faculty of Veterinary and Animal Science, Hajee Mohammad Danesh Science and Technology University (HSTU), Bangladesh.

Md. Mahmudul Hasan

Department of Physiology and Pharmacology, Faculty of Veterinary and Animal Science, Hajee Mohammad Danesh Science and Technology University (HSTU), Bangladesh.

Md. Bazlar Rashid

Department of Physiology and Pharmacology, Faculty of Veterinary and Animal Science, Hajee Mohammad Danesh Science and Technology University (HSTU), Bangladesh.

Mst. Misrat Masuma Parvez

Department of Physiology and Pharmacology, Faculty of Veterinary and Animal Science, Hajee Mohammad Danesh Science and Technology University (HSTU), Bangladesh.

*Author to whom correspondence should be addressed.


Abstract

An experiment was conducted at the Department of Physiology and Pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh to see the clinical effectiveness of turmeric extract with zinc oxide (ZnO) nanoparticles in a hot iron burn wound in the rabbit model. Data were collected on the healing rate, healing time, and White blood cells (WBC) count. Sixteen male New Zealand White rabbits were divided into four groups where group T0 served as the non-treated, T1 as burn healing using turmeric extract, T2 burn heals with turmeric extract and ZnO nanoparticles; and T3 burn heals with Bactrocin®. The results showed that the T2 treatment had the best (93±0.707%), T3 better (88.5±1.04%), T1 good (86.5±1.55%) performance, and while the T0 (67.5±0.86%) gave the worst performance. The T3 (26.5±0.60 days) and T2 treatments had the greatest results (24.5±0.6455 days) and required the fewest days of healing compared to T0 which takes a maximum of days (35.5±0.64). The study revealed that the WBC count was maximum in the non-treated group (at 0,1st, 2nd, 3rd, and 4th week) which is (5600±31.06, 9000±36.47, 8000±38.41, 7500±36.11 and 6000±43.11 cell/ul respectively). The T2 treatments showed lower WBC count during the entire studied period (0, 1st and 4th days) and T3 at (3rd week and 4th week). Overall, the results of the study showed that the use of turmeric extract and ZnO nanoparticles led to faster burn wound healing with a shorter time required, proving that treating burn wounds in rabbits without the use of the commercial drug is both feasible and recommended for practice.

Keywords: Curcuma longa, ZnO nanoparticles, commercial drug, wound, rabbit


How to Cite

Hoque, R., Islam, R., Hasan, M. M., Rashid, M. B., & Parvez, M. M. M. (2023). Effect of Turmeric (Curcuma longa) Extract with Zinc Oxide Nanoparticles Application on Burn Wound. Asian Journal of Research in Animal and Veterinary Sciences, 6(1), 50–57. Retrieved from https://journalajravs.com/index.php/AJRAVS/article/view/231

Downloads

Download data is not yet available.

References

George Broughton II, Janis JE, Attinger CE. The basic science of wound healing. Plastic and reconstructive surgery. 2006;117(7S):12S-34S.

Lugović-Mihić L, Duvančić T, Vučić M, Situm M, Kolić M, Mihić J. SDRIFE (baboon syndrome) due to paracetamol: case report. Acta Dermatovenerol Croat. 2013;21:113-7.

Reinke JM, Sorg H. Wound repair and regeneration. European surgical research. 2012;49(1):35-43.

Allacker K, De Troyer F, Velner R, Verhoeven M, Fremouw M. Integraged sustainability assessment of dwellings in the Belgian context. SASBE proceedings, Smart and Sustainable Built Environment; 2009.

Pasalar M, Mohammadi AA, Rajaeefard AR, Neghab M, Tolidie HR, Mehrabani D. Epidemiology of burns during pregnancy in southern Iran: Effect on maternal and fetal outcomes. World Appl Sci J. 2013; 28(2):153-8.

Senthil M, Brown M, Xu DZ, Lu Q, Feketeova E, Deitch EA. Gut- lymph hypothesis of systemic inflammatory response syndrome /multiple-organ dysfunction syndrome: validating studies in a porcine model. Journal of Trauma and Acute Care Surgery. 2006;60(5): 958-67.

Shahbaz MA, Goschütz M, Kaiser SA. Endoscopic anisole-LIF imaging of flame propagation and temperature fluctuations in a production SI engine. In8th European Combustion Meeting. 2017:18-21.

Ammon CJ. The isolation of receiver effects from teleseismic P waveforms. Bull. Seismol. Soc. Am. 1991;81(6):2504-10.

Akram M, Shahab-Uddin AA, Usmanghani KH, Hannan AB, Mohiuddin E, Asif M. Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol. 2010;55(2):65-70.

Srimal RC. Turmeric: a brief review of medicinal properties. Fitoterapia (Milano). 1997;68(6):483-93.

Yucel AF, Kanter M, Pergel A, Erboga M, Guzel A. The role of curcumin on intestinal oxidative stress, cell proliferation and apoptosis after ischemia/reperfusion injury in rats. Journal of Molecular Histology. 2011;42:579-87.

Akbar S, Tauseef I, Subhan F, Sultana N, Khan I, Ahmed U, Haleem KS. An overview of the plant-mediated synthesis of zinc oxide nanoparticles and their antimicrobial potential. Inorganic and Nano-Metal Chemistry. 2020;50(4):257-71.

Jayaseelan C, Rahuman AA, Kirthi AV, Marimuthu S, Santhoshkumar T, Bagavan A, Gaurav K, Karthik L, Rao KB. Novel microbial route to synthesize ZnO nanoparticles using Aeromonas hydrophila and their activity against pathogenic bacteria and fungi. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2012;90:78-84.

Rostan EF, DeBuys HV, Madey DL, Pinnell SR. Evidence supporting zinc as an important antioxidant for skin. International journal of dermatology. 2002;41(9):606-11.

Faisal S, Khan MA, Jan H, Shah SA, Shah S, Rizwan M, Akbar MT. Edible mushroom (Flammulina velutipes) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications. Nanotechnology. 2020 Nov 18;32(6):065101.

Saleem H, Zaidi SJ, Ismail AF, Goh PS. Advances of nanomaterials for air pollution remediation and their impacts on the environment. Chemosphere. 2022;287: 132083.

Seo K, Kim I, Jung S, Jo M, Park S, Park J, Shin J, Biju KP, Kong J, Lee K, Lee B. Analog memory and spike-timing-dependent plasticity characteristics of a nanoscale titanium oxide bilayer resistive switching device. Nanotechnology. 2011; 22(25):254023.

Mehedi M. Wound healing activity of nanoparticles with traditional plants in chemically burn rabbit model. M.S. Thesis. Department of Physiology and Pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur; 2021.

Bhutta ZA, Ashar A, Mahfooz A, Khan JA, Saleem MI, Rashid A, Aqib AI, Kulyar MF, Sarwar I, Shoaib M, Nawaz S. Enhanced wound healing activity of nano ZnO and nano Curcuma longa in third-degree burn. Applied Nanoscience. 2021;11:1267-78.

Sato H, Ebisawa K, Takanari K, Yagi S, Toriyama K, Yamawaki-Ogata A, Kamei Y. Skin-derived precursor cells promote wound healing in diabetic mice. Annals of plastic surgery. 2015;74(1):114-20.

Salam HA, Rajiv P, Kamaraj M, Jagadeeswaran P, Gunalan S, Sivaraj R. Plants: green route for nanoparticle synthesis. Int Res J Biol Sci. 2012;1(5):85-90.

Agarwal S, Sorkin M, Levi B. Heterotopic ossification and hypertrophic scars. Clinics in plastic surgery. 2017;44(4): 749-55.

Mehrabani D, Farjam M, Geramizadeh B, Tanideh N, Amini M, Panjehshahin MR. The healing effect of curcumin on burn wounds in rat. World journal of plastic surgery. 2015;4(1):29.